Protein Engineering, Vol 10, 1-6, Copyright © 1997 by Oxford University Press
H Nielsen, J Engelbrecht, S Brunak and G von Heijne
We have developed a new method for the identification of signal peptides
and their cleavage sites based on neural networks trained on separate sets
of prokaryotic and eukaryotic sequence. The method performs significantly
better than previous prediction schemes and can easily be applied on
genome-wide data sets. Discrimination between cleaved signal peptides and
uncleaved N-terminal signal-anchor sequences is also possible, though with
lower precision. Predictions can be made on a publicly available WWW
server.
ARTICLES
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
Department of Chemistry, Technical University of Denmark, Lyngby, Denmark.
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