Protein Engineering Design and Selection

ORIGINAL ARTICLES:

Johannes Schuchhardt, Gisbert Schneider, Joachim Reichelt, Dietmar Schomburg, and Paul Wrede

Local structural motifs of protein backbones are classified by self-organizing neural networks
Protein Eng. 1996 9: 833-842; doi:10.1093/protein/9.10.833 [Abstract] [PDF] [Request Permissions]  

Gonzalo de Prat-Gay

Association of complementary fragments and the elucidation of protein folding pathways
Protein Eng. 1996 9: 843-847; doi:10.1093/protein/9.10.843 [Abstract] [PDF] [Request Permissions]  

Kunchur Guruprasad, Tom L. Blundell, Sancai Xie, Jonathan Green, Bozena Szafranska, Robert J. Nagel, Karen McDowell, C.Ben Baker, and R.Michael Roberts

Comparative modelling and analysis of amino acid substitutions suggests that the family of pregnancy-associated glycoproteins includes both active and inactive aspartic proteinases
Protein Eng. 1996 9: 849-856; doi:10.1093/protein/9.10.849 [Abstract] [PDF] [Request Permissions]  

Tatsuki Kashiwagi, Denis Jeanteur, Mitsuru Haruki, Katsuo Katayanagi, Shigenori Kanaya, and Kosuke Morikawa

Proposal for new catalytic roles for two invariant residues in Escherichia coli ribonuclease HI
Protein Eng. 1996 9: 857-867; doi:10.1093/protein/9.10.857 [Abstract] [PDF] [Request Permissions]  

Young-Nam Park, Jun-ichi Aikawa, Makoto Nishiyama, Sueharu Horinouchi, and Teruhiko Beppu

Involvement of a residue at position 75 in the catalytic mechanism of a fungal aspartic proteinase, Rhizomucor pusilus pepsin. Replacement of tyrosine 75 on the flap by asparagine enhances catalytic efficiency
Protein Eng. 1996 9: 869-875; doi:10.1093/protein/9.10.869 [Abstract] [PDF] [Request Permissions]  

Nicola S. Clark, Ian Dodd, Danuta E. Mossakowska, Richard A.G. Smith, and Michael G. Gore

Folding and conformational studies on SCR1-3 domains of human complement receptor 1
Protein Eng. 1996 9: 877-884; doi:10.1093/protein/9.10.877 [Abstract] [PDF] [Request Permissions]  

P.G. Nugent, A. Albert, P. Orprayoon, J. Wilsher, J.E. Pitts, T.L. Blundell, and V. Dhanaraj

Protein engineering loops in aspartic proteinases: site-directed mutagenesis, biochemical characterization and X-ray analysis of chymosin with a replaced loop from rhizopuspepsin
Protein Eng. 1996 9: 885-893; doi:10.1093/protein/9.10.885 [Abstract] [PDF] [Request Permissions]  

Michael A. Roguska, Jan. T. Pedersen, Andrew H. Henry, Stephen M.J. Searle, C.Michelle Roja, Brian Avery, Mary Hoffee, Sherri Cook, John M. Lambert, Walter A. Blättler, Anthony R. Rees, and Braydon C. Guild

A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing
Protein Eng. 1996 9: 895-904; doi:10.1093/protein/9.10.895 [Abstract] [PDF] [Request Permissions]  

Gero Waschütza, Volkhart Li, Thomas Schäfer, Dietmar Schomburg, Carmen Villmann, Hayssam Zakaria, and Bernd Otto

Engineered disulfide bonds in recombinant human interferon-: the impact of the N-terminal helix A and the AB-loop on protein stability
Protein Eng. 1996 9: 905-912; doi:10.1093/protein/9.10.905 [Abstract] [PDF] [Request Permissions]  

Arthur E. Frankel, Chris Burbage, Tao Fu, Edward Tagge, John Chandler, and Mark Willingham

Characterization of a ricin fusion toxin targeted to the interleukin-2 receptor
Protein Eng. 1996 9: 913-919; doi:10.1093/protein/9.10.913 [Abstract] [PDF] [Request Permissions]  

Bernhard E. Fischer, Uwe Schlokat, Artur Mitterer, Grillberger Leopold, Manfred Reiter, Wolfgang Mundt, Friedrich Dorner, and Johann Eibl

Differentiation between proteolytic activation and autocatalytic conversion of human prothrombin. Activation of recombinant human prothrombin and recombinant D419N-prothrombin by snake venoms from Echis carinatus and Oxyuranus scutellatus
Protein Eng. 1996 9: 921-926; doi:10.1093/protein/9.10.921 [Abstract] [PDF] [Request Permissions]  

PROTOCOL:

Naomi E. Chayen

A novel technique for containerless protein crystallization
Protein Eng. 1996 9: 927-929; doi:10.1093/protein/9.10.927 [Abstract] [PDF] [Request Permissions]  

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